Sakthi kumar a morusin, a waterinsoluble prenylated. Nowadays we better know vesicles have importance in. Design, characterization and evaluation of latanoprost. Dls characterization of nonionic surfactant vesicles for potential nose to brain application. Preparation and characterization of giant niosomes chalmers. Physicalchemical characterization in view of biological applications federica rinaldi 1, elena del favero 2, johannes moeller 3,y, patrizia nadia hanieh 4, daniele passeri 5, marco rossi 5, livia angeloni 5, iole venditti 6, carlotta marianecci 4, maria carafa 4,z and ilaria fratoddi 7,z. Structure of niosomes niosomes are microscopic lamellar structures which are formed on the admixture of nonionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in. Pdf design and characterization of ofloxacin niosomes. Lot of research work is being carried out on preparation of niosomes for ophthalmic use having no significant effect on vision and its sustained release pattern. Request pdf preparation and characterization of niosomes containing resveratrol resveratrol rsv is an antioxidant present in red wine that may be used in. Contents of the powerpoint on niosomes drug delivery systems include. Pdf formulation and evaluation of niosomes researchgate. Artemisinin artloaded niosome and pegylated niosomes were prepared using two different techniques. Increase in the alkyl chain length has been found to lead to a higher ee.
Niosomes are nonionic surfactantbased vesicles with high promise for drug delivery applications. The vesicle is composed of a bilayer of nonionic surface active agents and hence the name niosomes. The niosome vesicles were characterized for their shape and surface. Nanosized lipid vesicles were physically characterized for entrapment efficacy and stability. Major aim of transdermal drug delivery sytem is to cross the stratum corneum. To address these issues, we have developed a novel niosome system composed of nonionic. Pdf preparation, characterization, cytotoxicity and. The unentrapped drug was separated from the niosomal suspension into the medium through osmosis cellulose membrane. In this paper the forming of vesicles from single chain surfactants, i. Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel. The niosomes were further characterized for their particle size, polydispersity index pi and zeta. Niosomes are unilamellar or multilamellar vesicles. The efficacy of the developed formulation was tested on mcf7 cells and.
Use of cholesterol, surfactants and there impacts methods of preparation evaluation of niosomes by various methods for different parameters application of niosomes such as in. Niosomes can act as carriers for radiopharmaceuticals and site specific vehicle for spleen and liver imaging. Niosomes nonionic surfactant vesicles are microscopic vesicles consisting of an aqueous core enclosed by a membrane of nonionic surfactants that form closed bilayer structures based on their amphiphilic nature uchegbu and vyas, 1998. Niosomes have been studied with different methods of administration including oral. The sedimentation behavior study and formulation stability tests against bile salt revealed that mixed niosomes prepared by combining span. Preparation, characterization of niosomes roopa karki et al. Niosomes serve as drug depots in the body which release the drug in a controlled manner through its bilayer providing sustained release of the enclosed drug. The niosomes are very small, and microscopic in size. The niosomes were formulated by combining the proportions of tween, span, and cholesterol. All spantype surfactants have the same head group with different alkyl chains. Introduction development of new drug, improving safety and efficacy of existing drugs is difficult, expensive and time consuming at present, no available drug delivery system behaves ideally achieving all the lofty goals encapsulation of the drug in vesicular structures is one of the promising system such as liposomes, niosomes. Niosomes can be used for oral delivery of drug thus protecting it from the hostile environment of the git and targeting to re.
Formulation, characterization and evaluation of morusin. Masters thesis 2016 preparationandcharacterization ofgiantniosomes. Nonionic surfactant vesicles or niosome are now widely studied as alternate to liposomes. Niosomes has gained tremendous popularity as ultimate drug carrier. Pdf preparation and characterization of chloramphenicol. Research paper preparation, optimization and characterization of ketoprofen proniosomes for transdermal delivery ajay b solanki1, jolly r parikh1 and rajesh h parikh2 1department of pharmaceutics and pharmaceutical technology, a. The alkyl chain of the surfactants varied between 10 and 18, while the number of oxyethylene units varied between 3 and 7. Niosomes are important from a technical viewpoint as they possess greater stability and avoid some disadvantages associated with liposomes such as variable purity of phospholipids pharmaceutics development and characterization. Characterization of niosomes prepared with various.
Part of theamerican studies commons this thesis is brought to you for free and open access by the graduate school at scholar. Recent advances in nonionic surfactant vesicles niosomes. The niosomes were further characterized for their particle size, polydispersity. Curcumin, a natural chemical compound found in curcuma longa, has been applied in multiple medicinal areas from antibiotic to antitumor treatment. Development and characterization of mixed niosomes for oral. Preparation and characterization of niosomes containing resveratrol. Physicochemical characterization of phresponsive and.
Development and characterization of niosomal gel for topical. They are being used in topical and transdermal products both contaning hydrophobic and hydrophillic drugs. Department of food science and technology, college of agriculture, isfahan university of technology, isfahan, 84156. Preparation and physicochemical characterization of topical niosomal formulation of 003003 minoxidil and tretinoin. Drug delivery through niosomes is one of the approaches to achieve localised drug action in regard to their size and low penetrability through epithelium and connective tissue, which keeps the drug localised at the site of administration.
Aswathy, rose mol k john abstract eye being a most delicate organ, ocular drug delivery is a challenge for the formulator. Dls characterization of nonionic surfactant vesicles for. Niosomes have been widely evaluated for controlled release and targeted delivery for the treatment of cancer, viral infections. The characterization of niosome is essential for the clinical applications. They can be rapidly prepared via microfluidics, allowing their reproducible production without. The major research in this field has made niosomes a very unique, yet simple, technique for the delivery of many drugs. Niosomes are important from a technical viewpoint as they possess greater stability and avoid some disadvantages associated with liposomes such as variable purity of phospholipids pharmaceutics development and characterization of niosomal drug delivery of gliclazide. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The aim of this paper is the preparation and characterization of drug delivery systems for a potential brain delivery by intranasal administration. Physicochemical characterization of phytosomes phytosome is a complex between a natural product and. Characterization and optimization of natural maltodextrin. Niosomes are preferred over other bilayer structures due to chemical stability, biodegradability, biocompatibility, low production cost, low toxicity, and easy storage and handling.
Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy srishti agarwal,a m. The assembly of rotary vacuum evaporator was set and solvent mixture was evaporated. Preparation and characterization of chloramphenicol niosomes and comparison with chloramphnicol eye drops 0. The niosome suspension placed over a glass slide and fixed over by drying at room temperature, the dry thin film of niosome suspension observed for the formation of vesicles. Pdf span 20based niosome was prepared by lipid film hydration technique and.
Alany3,4 1department of pharmaceutics, faculty of pharmacy, minia university, minia, egypt, 2department of pharmaceutical sciences, oregon state. The phresponsive niosomes interact and merge with the model biological membranes marianecci et al. Niosomes formed from span 40 and span 60 exhibited very high entrapment. Preparation and characterization of niosomes containing. Niosomes containing anticancer drugs, like, methotrexate and doxorubicin increases drug delivery to the tumor and tumoricidal activity of the drug. Highlights vesicular system introduction and types history of niosomes classification, impact, uses and drawbacks of surfactant in short and compiled impact of properties of niosomes such as chain length, hlb value, etc. The lipophilic groups are located in the interior of membrane while the hydrophilic groups are exposed to the aqueous medium. The synthesis of phresponsive amino acidic derivatives of tw20 can increase ph stability, and affect the fluidity and the supramolecular structure of the niosomes marianecci et al. Skin is the main target of topical and transdermal preparations. Pdf development and characterization of mixed niosomes for. However, the chemical structure of curcumin results in poor stability, low solubility, and rapid degradation in vivo, hindering its clinical utilization. Drug, non ionic surfactant and cholesterol were taken in different proportion and dissolved in solvent system into a 500 ml round bottom flask.
Preparation and characterization of niosomes niosomes were prepared by thin film hydration technique5. Niosomes characterization and its applications authorstream presentation. Finally optimized was selected for further characterization. Moreover, the current trend is to combine bpo with topical antibiotics. Introduction factors affecting niosomes preparation methods of preparation characterization of niosomes stability of niosomes applications of niosomes toxicity of niosomes presentation flow. Approach for designing solvents blend for herbal phytochemical extraction, comput.
Jufri study also showed that maltodextrin, dextrose. The niosome vesicles were characterized for their shape and surface morphology at. Synthesis and characterization of potential drug delivery. Hydrophilic silver nanoparticles loaded into niosomes. Formulation and characterization of topical gel of. Park, ac tive tumortherapeutic liposomal bacteriobot combining a drug paclitaxel encapsulated liposome with targeting bacteria salmonella. Niosomes are nonionic surfactant vesicles and, as liposomes, are bilayered. Particle sizes were determined and release kinetic of the optimized formulation was carried out by dialysis method. Design and characterization of ofloxacin niosomes article pdf available in pakistan journal of pharmaceutical sciences 266. Niosomal delivery of isoniazid development and characterization.
Development and characterization of niosomal gel for. In niosomes, the vesicles forming amphiphilic is a nonionic surfactant such as span 60 which is usually stabilized by addition of. Development and characterization of niosomal drug delivery. Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery article in journal of pharmaceutical sciences 994. Pdf rapid microfluidic preparation of niosomes for. Preparation and characterization of giant niosomes masters thesis in nanotechnology maryam homaei department of microtechnology and nanoscience mc2 chalmers university of technology gothenburg, sweden 2016. Targeted drug delivery can also be achieved using niosomes the drug is delivered directly to the body part where the therapeutic effect is required. Synthesis and characterization of potential drug delivery systems using nonionic surfactant niosome sukit leekumjorn university of south florida follow this and additional works at. General characteristics of niosomebiocompatible, biodegradable, nontoxic, non immunogenic andnoncarcinogenicthe ability of nonionic surfactant to form bilayer vesicles isdependant on the hlb value of the surfactant, the chemical structureof the components and the critical packing parameter niosomes can be characterized by their size. Preparation and physicochemical characterization of. Recent trends in niosome as vesicular drug delivery system.
307 731 1066 514 240 724 216 280 420 606 1419 514 1050 1098 800 901 176 401 1152 1135 1275 209 1371 207 1388 695 757 714 638 558 169 1198 92 853 1358 815 1013